Home > Who should take PrEP > Trans & non-binary

What is PrEP?

HIV PrEP is a medicine that stops you getting HIV. HIV is a virus that affects your immune system if left untreated. The most common way to get HIV in the UK is through unprotected anal, vaginal or frontal sex*.

Our About PrEP page covers all the information you need to help you decide if HIV PrEP is right sexual health choice for you.

*frontal sex is an alternative term for vaginal sex used by some trans and non-binary people.

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What else do you need to know?

Trans and non-binary people who have condomless penetrative anal or frontal sex may be at increased risk of HIV. PrEP can help to protect you from HIV. There is no evidence to suggest negative drug interactions between HIV PrEP and hormone therapy and is effective regardless of any gender-affirming surgeries that you may have had.

Some Trans and non-binary people may use contraception. PrEP can be used with all forms of contraception.

Download the HIV PrEP for trans and non-binary people leaflet

A downloadable leaflet (PDF) to help trans and non-binary people decide if HIV PrEP is right for them. It describes what HIV PrEP is, how you can access it, how it’s taken and how it supports sexual health.

Trans feminine person

PrEP offers protection during vaginal/frontal and anal sex. It’s safe to use for trans women and trans feminine people and is effective regardless of any gender-affirming surgeries that you’ve had, including vaginoplasty.

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Trans masculine person

PrEP offers protection during frontal and anal sex. It’s safe to use for trans masculine and non-binary people and is effective regardless of any gender-affirming surgeries that you’ve had.

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Trans People Taking PrEP

My Genderation is an ongoing film project focusing on trans lives and trans experiences. All our content is created by trans people, about trans people, for a much wider audience. Currently run by Fox Fisher and Owl Fisher.

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#PrEP4women

Research shows that PrEP works for women – including trans women – yet across the world women’s access to PrEP is still low.

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